|
KMID : 0848120210460020067
|
|
International Journal of Oral Biology
2021 Volume.46 No. 2 p.67 ~ p.73
|
|
|
New conceptual approaches toward dentin regeneration using the drug repositioning strategy with Wnt signaling pathways
|
|
Lee Eui-Seon
Kim Tae-Young
Aryal Yam Prasad
Kim Ki-Hyun
Byun Seong-Soo
Song Dong-Ju
Shin Ye-Jin
Lee Dany
Lee Joo-Heon
Jung Gil-Young
Chi Seung-Hoon
Choi Yoo-Lim
Lee Young-Kyun
An Chang-Hyeon
Kim Jae-Young
|
|
|
Abstract
|
|
|
|
This study summarizes the recent cutting-edge approaches for dentin regeneration that still do not offer adequate solutions. Tertiary dentin is formed when odontoblasts are directly affected by various stimuli. Recent preclinical studies have reported that stimulation of the Wnt/β-catenin signaling pathway could facilitate the formation of reparative dentin and thereby aid in the structural and functional development of the tertiary dentin. A range of signaling pathways, including the Wnt/β-catenin pathway, is activated when dental tissues are damaged and the pulp is exposed. The application of small molecules for dentin regeneration has been suggested as a drug repositioning approach. This study reviews the role of Wnt signaling in tooth formation, particularly dentin formation and dentin regeneration. In addition, the application of the drug repositioning strategy to facilitate the development of new drugs for dentin regeneration has been discussed in this study.
|
|
|
KEYWORD
|
|
|
Tooth, Drug repositioning, Wnt signaling pathway
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
 
|